neoFroxx® Silver Nitrate Pure EP, USP (pharma grade), CAS: 7761-88-8

Used as a chemical intermediate, catalyst, disinfectant, and laboratory reagent; Used in photography and in the manufacturing of mirrors, inks, and pharmaceuticals; Used to cauterize wounds, dye hair, and color porcelain; [HSDB]

Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

To elucidate the possible mechanism of initiation of lipid peroxidation in silver nitrate treated erythrocytes, the effect of AgNO3 on Hb catalyzed peroxidation of phospholipid liposomes was studied. Ag+ significantly increases the rate of Hb-catalyzed peroxidation. The inhibition of this effect by superoxide dismutase and catalase suggests that superoxide radical and H2O2 are involved. It was demonstrated also that Ag+ potentiates the Hb autoxidation and increases the binding of Hb to the erythrocyte membrane.

PMID:3707552

Hazardous Substances Data Bank (HSDB)

Silver nitrate exhibits antiseptic, germicidal, astringent, and caustic or escharotic activity. These effects may result from silver ions readily combining with sulfhydryl, carboxyl, phosphate, amino, and other biologically important chemical groups. When silver ions interact with proteins, physical properties of the protein are usually altered; the protein may be denatured and precipitation usually occurs. Silver ions act on the surface of bacteria causing substantial changes in the cell wall and membrane. The germicidal activity of silver nitrate may be attributed to precipitation of bacterial proteins by liberated silver ions.

American Hospital Formulary Service-Drug Information 88. Bethesda, MD: American Society of Hospital Pharmacists, 1988 (Plus supplements)., p. 1529

Hazardous Substances Data Bank (HSDB)