neoFroxx® Glycerin 87% pure EP (pharma grade), CAS: 56-81-5

Used as a solvent, humectant, plasticizer, emollient, sweetener, coating for paper, antifreeze for automobiles, and fluid for gas meters, hydraulic jacks, and shock absorber; Also used to make nitroglycerol (dynamite), cosmetics, soaps, liqueurs, confectioneries, inks, lubricants, glues; and medications; Also used to keep fabrics pliable; to preserve printing on cotton; and to defrost windshields; [HSDB; Merck Index]

Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.

Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

DrugBank

Glycerin (glycerol) and sorbitol are hyperosmotic laxatives.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011

Hazardous Substances Data Bank (HSDB)

When administered rectally, glycerin and sorbitol exert a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexly stimulating evacuation. The extent to which the simple physical distention of the rectum and the hygroscopic and/or local irritant actions are responsible for the laxative effects of some of these drugs is not known. Only extremely high oral doses of sorbitol (25 g daily) or glycerin exert laxative action.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011

Hazardous Substances Data Bank (HSDB)

/Glycerin/ decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

Physicians Desk Reference for Ophthalmic Medicines 38th ed. Thomson Reuters. Montvale, NJ 2010.

Hazardous Substances Data Bank (HSDB)

The physicochemical effects of a series of alkanols, alkanediols and glycerol on erythrocyte shape and hemolysis at 4 and 20 degrees C were examined. We calculated the dielectric constant of the incubation medium, Ds, and the dielectric constant of the erythrocyte membrane Dm in the presence of organic solutes. The ratio Ds/Dm = -38.48 at 20 degrees C defines the normal biconcave shape in a medium without hemolytic agents. A decrease in Ds/Dm favors externalization or internalization with consequent hemolysis. Alkanols and alkanediols convert biconcave erythrocytes into echinocytes, which is accompanied by an increase in the projected surface area. Glycerol converts biconcave erythrocytes into stomatocytes, which was accompanied by a marginal decrease in the projected surface area. Progressive externalization in alkanols and alkanediols or internalization in glycerol resulted in a decrease in the projected surface area and the formation of smooth spheres. The degree of shape change induced was related to the degree of hemolysis and the ratio Ds/Dm. A decrease in temperature reduced both the degree of shape change and hemolysis. /Thus/ physicochemical toxicity may be a result of a temperature dependent hydrophobic interaction between the organic solutes and the membrane and is best interpreted by the ability of the solutes to change Ds and Dm.

PMID:8634318

Hazardous Substances Data Bank (HSDB)